St. Anthony College Calapan City, Inc. became a full-fledged college in 2004 and is registered with the Securities and Exchange Commission as a private non-sectarian stock corporation. The college is headed by the President/CEO supported Board of Directors. It was granted a permit by the Commission on Higher Education (CHED) to open initial flagship programs in Bachelor of Science in Nursing and Bachelor of Science in Information technology which earned distinctions to the performance of graduates in government examinations (NLE) and work performance of BSIT graduates in their field of employments. The college subsequently offered Bachelor of Secondary Education, Bachelor of Science in Computer Engineering, Bachelor of Science in Business Administration Major in Financial Management and Marketing, Bachelor of Science in Hotel and Restaurant Management, BS in Tourism Management, Diploma in Midwifery, Maritime and TESDA programs.
In the school year 2014-2015, the college started offering Basic and Junior High School Education. Subsequently, in school year 2016-2017 Senior High School was opened with an initial total enrollees of 731 students offering Academic and Technical Vocational Livelihood Tracks.
The college is now ready to cater k to 12 programs in its newly constructed Bayanan 1 campus.